In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on [...]
The intersection of molecular chaperones and neurodegeneration is an intensely studied area because of the potential of manipulating the expression of molecular chaperones to thwart the progression of debilitating diseases. Encompassing contributions from leading experts, "Molecular Chaperones and P[...]