With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory[...]

Principles of Scientific Methods focuses on the fundamental principles behind scientific methods. The book refers to "science" in a broad sense, including natural science, physics, mathematics, statistics, social science, political science, and engineering science. A principle is often abstract and [...]

Nothing can better help students understand difficult concepts than working through and solving problems. By providing a strong pedagogical framework for self study, this Solutions Manual will give students fresh insights into concepts and principles that may elude them in the lecture hall. It featu[...]