Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasin[...]
Presents a practical understanding of property fundamentals and structure modification strategies that can be applied to improving drug leads. This title offers a fresh approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related[...]