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  1. Drug-Like Properties: Concepts, Structure Design and Methods: From ADME to Toxicity Optimization (Inbunden)

    av

    Edward H. Kerns, Li Di

    ISBN: 9780123695208 - UTGIVEN: 200802

    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasin[...]

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  2. Drug Discovery Bundle (Inbunden)

    av

    Richard B. Silverman, Edward H. Kerns

    ISBN: 9780123748676 - UTGIVEN: 2008-10-03

    Presents a practical understanding of property fundamentals and structure modification strategies that can be applied to improving drug leads. This title offers a fresh approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related[...]

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