Biosimulation in Drug Development

Biosimulation in Drug Development gives the first comprehensive survey of a broad range of pharmaceutically relevant topics and provides an extensive and clear introduction to the novel and revolutionary tool of biosimulation. This book presents modelling concepts as well as application examples for [...]
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Biosimulation in Drug Development gives the first comprehensive survey of a broad range of pharmaceutically relevant topics and provides an extensive and clear introduction to the novel and revolutionary tool of biosimulation. This book presents modelling concepts as well as application examples for metabolic networks, cells, organs and the body as a whole. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions. Many of the authors are members of the BioSim Network of Excellence (LSHB-CT-2004-005137) that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a broad demonstration of Systems Biology in the pharmaceutical industry.