Drug-Drug Interactions

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new materia [...]
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Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on: * key interplay between transporters and enzymes in drug metabolism and drug interactions * the integral role of pharmacogenetics in metabolism-based drug-drug interactions * in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction) * in silico approaches enabling structure-activity and structure-function studies * high-throughput screening and GLP methods for evaluating drug interactions in vitro * the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.