Practical Flow Cytometry in Haematology Diagnosis

This book aims to provide answers to the diagnostician who cannot turn to reference books when the morphology or immunophenotype are atypical. There are currently a number of excellent textbooks describing the presentation, morphology, immunophenotype, cytogenetic profile and prognosis of leukaemias [...]
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This book aims to provide answers to the diagnostician who cannot turn to reference books when the morphology or immunophenotype are atypical. There are currently a number of excellent textbooks describing the presentation, morphology, immunophenotype, cytogenetic profile and prognosis of leukaemias and lymphomas in accordance with the current World Health Organisation classification of tumours of haemopoietic and lympohoid tissues. Many of these books, however, are reference books to be consulted when a particular diagnostic entity is being considered in the laboratory. This book will act as a clinical manual to help the diagnostician on the job. At the core of this text is an appreciation of clinical, morphological and immunophenotypic correlation and the importance of constant liaison and discussion between the medical and scientific teams. The authors present a logical practical approach to the diagnosis of blood disorders, both neoplastic and reactive and to look at other diagnostic applications of flow cytometry in non-neoplastic haematology diagnosis. The book is illustrated throughout with worked examples to illustrate a particular point or phenomenon - flow cytometry has a strong visual component which is often better shown as a scatter plot rather than in words. This practical illustrated manual of diagnostic flow cytometry is not a reference book but a core manual that can be read from beginning to end, that can act as an introductory text for trainees but also provide some wisdom in difficult circumstances. It will assist the reader in making a diagnosis and also in understanding the limitations of the technique and the pitfalls that can confuse even the most experienced.